Das entscheidende Experiment gelingt 2004, in einem Labor der University of Pennsylvania in Philadelphia. Katalin Karikó blickt auf die Messwerte und kann es zunächst kaum glauben. Die Zellen, die in der Kulturschale wachsen, sondern einen Eiweißstoff ab – weil die ungarische Wissenschaftlerin eine Botschaft in Form von RNA geschickt hat. Der Erste, mit dem sie die Ergebnisse bespricht, ist der Amerikaner Drew Weissman. Die Biochemikerin und der Immunologe ergänzen sich in ihrer Expertise; im Jahr darauf veröffentlichen sie gemeinsam ihre Ergebnisse im Fachjournal „Immunity“.
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