Jährlich werden in Afrika fast 140 Krankheitsausbrüche festgestellt. Genomsequenzierungen können dabei die wissenschaftlichen Beweise liefern, welche die Gesundheitssysteme benötigen, um diese Ausbrüche besser zu verhindern, zu identifizieren und nachzuverfolgen. Neuen Krankheitserregern kann früher Einhalt geboten und Krankheiten wie COVID-19, Polio, Malaria, Tuberkulose, HIV/AIDS, Cholera und Ebola sind besser in den Griff zu bekommen. Die Erkenntnisse aus der Erregergenomik helfen beispielsweise bei der Zuteilung und Entwicklung wertvoller medizinischer Güter wie Diagnostika, Medikamente und Impfstoffe. So beschreibt es auch die Gesundheitsstrategie für Afrika 2016-2030 der Afrikanischen Union, in der die Entschlüsselung des Genoms von Pathogenen als „entscheidender Bestandteil wirksamer Systeme der Krankheitsüberwachung“ bezeichnet wird.
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