Die Liste der gescheiterten Arzneimittelkandidaten gegen Alzheimer ist lang und wird immer länger. Zuletzt musste Roche bekanntgeben, dass ihr Wirkstoff-Kandidat Gantenerumab in zwei größeren Studien das Ziel verfehlte. Er konnte weder den Krankheitsverlauf bei Alzheimer-Patienten im Frühstadium signifikant verzögern, noch die Ablagerungen von Beta-Amyloiden zwischen den Nervenzellen im erhofften Ausmaß entfernen. Dass bislang keine Durchbrüche in der Therapie der tückischen Erkrankung erzielt werden konnten, liegt vor allem daran, dass die genaue Pathogenese der nicht-erblichen Hauptform der Alzheimer-Erkrankung immer noch ungeklärt ist.
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